Campobasso is the administrative center of Molise, whose other province is Isernia. The region ranks 19th in both size (4,438 square kilometers) and population (329,000).

The recent DOC of Molise takes in a number of Italian and native varieties, creating new possibilities for producers who are striving to establish an identity with wine beyond the region. The rolling hills and the mild Adriatic climate of Molise favor wines of class, though the evidence in bottle has been scarce so far. The IGT category of Osco or Terre degli Osci refers to the Oscan people who inhabited Molise in prehistoric times. The other IGT category is Rotae.